OncoEng centres on a transformational and systems engineering approach Metastatic Bone Disease (MBD) in the spine using a framework combining advanced image-based modelling and cutting edge manufacturing to enable an optimised, metamaterial-based minimally invasive implant (MII). Long-term patient impact will be enabled by partnership with the industry and healthcare sectors, as well as other globally leading academic units.
Researchers will develop new approaches to patient imaging and computer modelling, enabling them to track tumour development in the spine over time and how it might be weakening individual vertebrae.
The information would be compared with the loading on the spine, enabling clinicians to predict which of the vertebrae is at risk of fracturing.
Finally a new medical device will be developed to enable treatment of vertebrae at a high-risk of collapse to be supported by an implant inserted into the spine using minimally invasive techniques.
A minimally invasive device (figure below) will be optimally designed using a multiscale approach; the concept will be tested both computationally and experimentally going beyond standard in vitro test methods. This will include an initial, novel in silico trials framework and adverse scenarios which are more likely to induce fracture.
A new type of minimally invasive vertebrae implant
A minimally invasive device (figure right) will be optimally designed using a multiscale approach; the concept will be tested both computationally and experimentally going beyond standard in vitro test methods.
This will include an initial, novel in silico trials framework and adverse scenarios which are more likely to induce fracture.
“ This project allows us to expand our expertise in the analysis, optimisation and 3D printing of structural metamaterials. By working as part of the multidisciplinary team we aim to apply the new approaches and knowledge to improve the quality of life of late-stage cancer suffers.
We will also be able to apply some of these new approaches back into the aerospace and mechanical engineering sectors where advanced meta-materials have a wide range of potential applications.”
The 6 scientific objectives that provide an integrated approach to realising the overall aims and vision of OncoEng are:
World Cancer Day
The Leeds Cancer Research Centre will be delivering a mini-conference as part of World Cancer Day on the 3 rd February (World Cancer Day is actually on 4th Feb). OncoEng is very supportive of the…
OncoEng Quarterly Meeting
Great OncoEng Quarterly get together last week. The Management Board Meeting in the morning was eagerly attended by all the researchers and academics. In the afternoon we were joined by Dr Sherron Furtado, Craig Gerrand, Sarah Astill and David Lunn to…
Research Challenge 2: Modelling Spinal Biomechanics
Research challenge 2 (RC2) is centred around the need for the development of an advanced spinal rigid-body modelling technique. This is required to determine the expected vertebral loads and motion across a range of daily…
Research Challenges: Development and Assessment of MII Build Technology
3D printing revolutionises medical device technology by allowing personalised devices to be created within a short period of time, and at lower costs than traditional manufacturing methods. OncoEng aims to utilise 3D printing to create…
MetUp UK: Darker Side of Pink Exhibition
Today I visited the #DarkerPink exhibition at the Danum Gallery and Museum in Doncaster. The presence of dark pink figures, listening to their stories as I stood in front of them, really brought home the…
OncoEng Kickoff Meeting
The 10th of June marked the beginning of OncoEng, in which academics, early-stage researchers, patient advocates, and representatives from invested companies met in Weetwood Hall, Leeds for the kick-off meeting. The day began with a…